PATHOLOGICAL ANATOMY OF INFECTION CAUSED BY SARS-COV-2

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Abstract

Autopsy data from 80 patients who died of the COVID-19 infection were analysed. Using macro- and microscopic studies, specific features of pathological processes in various organs were identified. The obtained experimental data, along with information from literature sources, allowed conclusions to be drawn about the mechanisms of damaging internal organs and body systems, as well as assumptions to be made about individual links in the pathogenesis of COVID-19. The thanatogenesis of the disease and the main causes of death are discussed, including acute cardiopulmonary failure, acute renal failure, pulmonary thromboembolism, shock involving multiple organ failure and sepsis. The critical importance of autopsy is emphasized, which provides valuable information on the morphological substrate for this infection closely associated with possible clinical manifestations.

About the authors

E. A. Kogan

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0002-1107-3753

Dr. Sci. (Med.), Prof., Corresponding Member of the Russian Academy of Natural Sciences (RANS), Head of the A. I. Strukov Department of Pathological Anatomy,

Moscow

Russian Federation

Yu. S. Berezovsky

Central Tuberculosis Research Institute

Email: report-q@yandex.ru
ORCID iD: 0000-0001-5904-0021

Head of the Pathology Department,

Moscow

Russian Federation

D. D. Protsenko

I. M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: chief@medprint.ru
ORCID iD: 0000-0002-5851-2768

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

Russian Federation

T. R. Bagdasaryan

Central Tuberculosis Research Institute

Email: cniit@ctri.ru
ORCID iD: 0000-0001-9910-1570

Cand. Sci. (Med.), Chief Physician,

Moscow

Russian Federation

E. M. Gretsov

Central Tuberculosis Research Institute

Email: gem2505@yandex.ru
ORCID iD: 0000-0002-2337-4692

Pathologist,

Moscow

Russian Federation

S. A. Demura

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-9717-5496

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

Russian Federation

G. A. Demyashkin

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-8447-2600

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

Russian Federation

D. V. Kalinin

A. V. Vishnevsky National Medical Research Center

Email: dmitry.v.kalinin@gmail.com
ORCID iD: 0000-0001-6247-9481

Cand. Sci. (Med.), Head of the Pathology Department,

Moscow

Russian Federation

A. D. Kukleva

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0002-6690-3347

Postgraduate Student of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

Russian Federation

E. V. Kurilina

National Medical Research Center of Cardiology

Email: ellakurilina@yandex.ru
ORCID iD: 0000-0002-3208-534X

Head of the Pathology Department,

Moscow

Russian Federation

T. P. Nekrasova

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-6376-9392

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

Russian Federation

N. B. Paramonova

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-5380-7113

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

Russian Federation

A. B. Ponomarev

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0002-4242-5723

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

Russian Federation

S. G. Radenska-Lopovok

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0002-4669-260X

Dr. Sci. (Med.), Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

Russian Federation

L. A. Semyonova

Central Tuberculosis Research Institute

Email: lu.kk@yandex.ru
ORCID iD: 0000-0002-1782-7763

Cand. Sci. (Med.), Senior Researcher of the Department of Pathomorphology, Cell Biology and Biochemistry,

Moscow

Russian Federation

A. S. Tertychny

I. M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-5635-6100

Dr. Sci. (Med.), Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

Russian Federation

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Copyright (c) 2020 Kogan E.A., Berezovsky Y.S., Protsenko D.D., Bagdasaryan T.R., Gretsov E.M., Demura S.A., Demyashkin G.A., Kalinin D.V., Kukleva A.D., Kurilina E.V., Nekrasova T.P., Paramonova N.B., Ponomarev A.B., Radenska-Lopovok S.G., Semyonova L.A., Tertychny A.S.

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